Antifungal Activity of Moringa (Moringa Oleifera Lamk.) Seed Oil from East Nusa Tenggara, Indonesia, against Malassezia Furfur Causes Seborrheic Dermatitis
Abstract
Hair is skin adnexa in the form of a dermis layer that functions to protect the scalp from environmental influences such as ultraviolet rays, temperature, and humidity. Oily hair can trigger the growth of Malassezia furfur (M. furfur), which causes seborrheic dermatitis. Moringa seed oil contains phytosterol compounds and fatty acids, which can inhibit the growth of fungi. This study aimed to determine the antifungal activity of moringa seed oil from East Nusa Tenggara, Indonesia, against M. furfur. The study was conducted in vitro using the well diffusion method with inhibition zone parameters, minimum inhibitory concentration test by liquid dilution, and minimum fungicidal concentration test by counting the number of colonies. Moringa seed oil at concentrations of 7.5, 10, and 12.5% had antifungal activity against M. furfur with inhibition zones of 14.5 ± 1.32 mm (strong), 18.3 ± 3.51 mm (strong), and 26.3 ± 2.36 mm (very strong) with a minimum inhibitory concentration of 2.50% and a minimum fungicidal concentration of 5.00%. Moringa seed oil can be developed as an antifungal, where the greater the concentration, the greater the inhibitory and killing power against M. furfur. The novelty of this study is the antifungal activity test of moringa seed oil from East Nusa Tenggara that was obtained by a cold pressed method targeting the fungus M. furfur ATCC 14521 using the well diffusion method.
Keywords: Moringa oleifera Lamk., fatty acids, phytosterols, Malassezia furfur.
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