Journal of Hunan University Natural Sciences

The Journal of Hunan University Natural Sciences is the leading Chinese academic journal that publishes articles in all areas of natural sciences. The Journal is meant to serve as a means of communication and discussion of important issues related to science and scientific activities. The Journal publishes only original articles in English which have international importance. In addition to full-length research articles, the Journal publishes review articles. Papers can be focused on fundamental research leading to new methods, or adaptation of existing methods for new applications.

Articles for the Journal are peer-reviewed by third-party reviewers who are selected from among specialists in the subject matter of peer-reviewed materials.

The Journal of Hunan University Natural Sciences is a kind of forum for discussing issues and problems facing science and scholars, as well as an effective means of interaction between the members of the academic community. The Journal of Hunan University Natural Sciences is read bya large number of scholars, and the circulation of the journal is constantly growing.

The Journal of Hunan University Natural Sciences publishes special issues on various and relevant topics of interest to the scientific community.

The Journal of Hunan University Natural Sciences is indexed by Web of Science, Scopus, Current Contents, Geobase and Chemical Abstracts.


Articles containing fundamental or applied scientific results in all areas of the natural sciences are accepted for consideration.

The Editorial Board of the Journal of Hunan University Natural Sciences is composed of 25 members and is chaired by Academician Chen Zhengqing. Editor-in-chief is Prof. Yi Weijian.


Frequency of publication: monthly

ISSN: 1674-2974

Access to all articles on the website is open, does not require registration or payment.

Journal articles are licensed under the CC BY 4.0 Creative Commons Attribution 4.0 License.

The Journal of Hunan University Natural Sciences takes care of maintaining electronic versions of articles. Data safety is ensured by backing up digital data in accordance with internal regulations. Logical and physical data migration is also provided. Cloud technologies are applied.

For further information, please contact:


Address: Lushan Road (S), Yuelu District, Changsha, Hunan Province, Zip Code: 410082 (Editorial Department of Journal)

Paper Submission 



Submission open for Volume 49, Issue 5, May, 2022.

Dear Authors,

Please submit your manuscripts through our Online Submission System or directly to the Chief -Editor's e-mail
Deadline:  May 31, 2022.

Journal of Hunan University Natural Sciences is an international, peer-reviewed open - access journal on all aspects of natural sciences published monthly online.
Manuscripts are peer-reviewed. The first decision is given to authors about 20-30 days after submission; acceptance for publication after revisions is done within seven days.
Journal of Hunan University Natural Sciences provides an advanced forum on all aspects of natural sciences. It publishes reviews, research papers, and communications. We aim to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that everyone can reproduce the results. Electronic files and software regarding the full details of the calculation or experimental procedure can be deposited as supplementary electronic material if unable to be published in a normal way.

The journal covers physics, chemistry, engineering, environmental, earth sciences and biology.
•    Biosciences and Bioengineering;
•    Computer and Information Science;
•    Chemistry;
•    Earth-Aerospace-Marine Science;
•    Electrical and Electronic Engineering;
•    Education;
•    Engineering;
•    Energy;
•    Environmental Sciences;
•    Economy;
•    Finance;
•    Materials Science;
•    Mathematics;
•    Medicine;
•    Neurosciences ;
•    Physics;
•    Pharmaceuticals.

The authors should prepare the articles strictly according to the template. Please check the link

All articles published in are published in full open access. In order to provide free access to readers, and to cover the costs of peer review, copyediting, typesetting, long-term archiving, and journal management, an article processing charge (APC) of EUR 430 applies to papers accepted after peer - review.
Submitted papers should be well formatted and use good English. Authors may use our English editing service (EUR 70-100) prior to publication or during author revisions. The articles that native English speakers do not edit are not allowed for publication.
The journal publishes articles in English or Chinese.
Articles published in the Journal of Hunan University Natural Sciences will be Open-Access articles distributed under the terms and conditions of the Creative Commons Attribution License (CC BY). The copyright is retained by the author(s).

Posted: 2022-05-13 More...
More Announcements...

Last Research Articles

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease-19 (COVID-19), has become a global health issue. Spike proteins from the virus have a vital role in infection. Herbal medicines such as Lagerstroemia, Euphorbia hirta, and Kleinhovia hospita have several pharmacological functions such as anticancer, antiviral, and antioxidant because of their bioactive compound content. Based on an in silico study, this research was conducted on the possibility of phytochemicals from herbal Lagerstroemia, E. hirta, and K. hospita to inhibit spike protein SARS-CoV-2. A three-dimensional (3D) compound structure of each herbal medicine was docked with HR protein using AutoDock Vina software. The docking result, which has the best binding energy value, is continued with the analysis of molecular dynamics simulation. Lagerine, rutin, and nicotiflorin compounds might bind to proteins with lower binding energy. Protein was unstable when complexed with compounds compared with control, as seen from the root-mean-square deviation (RMSD) value. Therefore, this research is pre-experimental to inhibit SARS-CoV-2 spike proteins by herbal medicines.


Keywords: COVID-19, Euphorbia hirta, Kleinhovia hospita, Lagerstroemia, severe acute respiratory syndrome-coronavirus 2.


Jantje Wiliem Souhaly, Sapti Puspitarini, M. Hermawan Widyananda, Nashi Widodo

Biodiesel production is worthy of continued study and optimization of production procedures due to its environmentally beneficial attributes and renewable nature. This study aims to investigate the optimum conditions and optimum production unit for the production of biodiesel from waste vegetable oil. Two production processes were considered: one using base-catalyzed transesterification, and the second is non-catalytic transesterification (using methanol at very high temperature and pressure). Through optimizing the process variables that affect the yield and purity of biodiesel, optimal transesterification conditions that produce maximum biodiesel yield were reached. Furthermore, the optimum production process that consumes less heating and cooling energy and has less environmental impact was identified. The surface plot, contour plot, and the Pareto chart were used to represent and relate the influence of the process variables on biodiesel yield. The parameters were correlated with the biodiesel yield using linear regression analysis. HYSYS model was developed for both techniques using the optimum conditions to figure out the optimum reactor dimensions required for the two processes at these conditions. A detailed comparison between the two processes was discussed, including the CO2 emissions for the two processes, the energy required for both, and energy integration to minimize the energy supplied as possible. Finally, economic aspects and cost analysis were also discussed.


Keywords: base-catalyzed transesterification, supercritical methanol transesterification, Pareto chart, contour plot, surface plot, heat integration.


Nessren M. Farrag, Mamdouh A. Gadalla, Mai K. Fouad

The long-term effect of a vasectomy was investigated in this work. Twenty sexually mature New Zealand white male rabbits (Oryctolagus cuniculus) of proven fertility were used. The maturity of these rabbits was determined by the age of about 14 months from birth, palpation of genitalia, and examination of semen samples. The animals were divided into four groups: four rabbits were used as controls, and sixteen rabbits were vasectomized. After six months after vasectomy, we start taking a sample by exposing each group in one month after the previous one. The operated ducts revealed an increase in size in 7-8 months after vasectomy. The initial and terminal segments appeared greatly swollen and distended with fluid, resulting in the whole epididymis's increasing weight. Histological changes included a drop in the height of the lining epithelium and microvilli of the epididymis. After eight months of vasectomy, dilatation in the epididymal tubules increased its diameters, especially in the terminal segment. This caused an increase in the thickness of intertubular connective tissue. In addition, there was distension due to the intratubular pressure increase. This resulted in the tubular wall rupture and extravasation of spermatozoa into the interstitial tissue after 6-7 months from vasectomy. Eight months later, the epithelial lining was returned. The examination of morphological changes due to vasectomy was also investigated.


Keywords: vasectomy, excurrent duct, epididymis, lumen, epithelium.


Ali Thoulfikar A. Imeer, Abdul Amir H. Kadhum

The growth and development of children under five (toddlers) affect their health conditions. Each region uniquely identifies the main factors influencing the toddler's health condition. The status of toddlers is generally categorized into two classes, namely normal and abnormal, so it is often found that the condition of toddler status is in the form of multi-response variables. Combining the two binary classes' response variables will form a multiclass response variable requiring different model development techniques and performance measurements. This study aims to determine the main factors that affect toddlers' health conditions in Malang, Indonesia, build multiclass logistic regression and decision tree classification models, and measure the model's performance. The Chi-square test selected predictor features as the input of multiclass logistic regression and decision tree models. From the feature selection, four main factors influence the status of toddlers' health conditions in Malang: the mother's history of diabetes before pregnancy, the father's blood pressure, psychological condition, and drinking water quality. The decision tree model performs better than the logistic regression model on the various performance measures used.


Keywords: Chi-square test, decision tree, logistic regression, multiclass classification, variable selection.



Waego H. Nugroho, Samingun Handoyo, Yusnita J. Akri, Agus D. Sulistyono

The study aims to examine plasma nitric oxide concentration and its relationship to T-786C gene polymorphism levels in the development of coronary heart disease in young people. Reduced nitric oxide (NO) bioavailability and endothelial nitric oxide synthase (eNOS) T786C gene polymorphism have been identified as risk factors for the development of coronary heart disease. This cross-sectional study was conducted in SRM Medical College Hospital and Research Centre on 200 angiographically proven CHD subjects attending the Department of Cardiology and medicine and 100 controls from MHC in the age group of ≤ 45 years. Overnight fasting plasma samples were obtained to evaluate lipid profile and nitric oxide by Griess reaction in UV spectrophotometry utilizing the ELISA technique. Polymerase Chain Reaction and Restricted fragment length polymerase amplify the eNOS gene T-786C. As a result, NO levels in plasma were significantly lower in CHD patients than in controls. In addition, C allele carriers of the eNOS T786C polymorphism showed significantly lower mean plasma NO levels than T allele carriers (P < 0.001). Our findings suggest that a lower plasma NO level is related to an increased risk of CHD. Furthermore, the eNOS T786C polymorphism is a significant risk factor for CHD development by lowering NO levels in the plasma. However, the eNOS T786C polymorphism influences the severity of CHD.

Keywords: coronary heart disease, endothelial nitric oxide synthase, gene polymorphism, nitric oxide.


Thirunavukkarasu Jaishankar, Meera Shivasekar, V. M. Vinodhini
Journal of Hunan University Natural Sciences
Copyright 2012-2022
(e-ISSN: 1674-2974 )