Potential Drug-Related Problems in Ischemic Stroke Patients and Their Effect on Clinical Outcomes at RS X, East Jakarta, in 2019
Abstract
Background, Stroke is a circulatory disorder of the brain caused by narrowing of blood vessels due to comorbidities such as hypertension and hyperlipidemia. Thus, causing functional disorders of the brain in the form of neurological deficits/nerve paralysis for 24 hours or more. Treatment of stroke with comorbidities will result in Drug Related Problem (DRP). The purpose of this study was to determine DRPs and their effects on clinical outcomes in ischemic stroke patients at RS X East Jakarta in 2019. Methodology, This study uses a cross-sectional design, and data collection was carried out retrospectively on 120 medical records of ischemic stroke patients in 2018. The data obtained were analyzed with SPSS, for drug interactions based on literature and observations of prescriptions for ischemic stroke patients, The results of the study found 36.07% drug interactions, 29.51% indications without drugs, 9.29% drugs without indications, 6.56% frequency of administration exceeding the rules of use, 5.46% doses too high, 4.37% frequency of administration less than the rules of use, 2.73% doses too low, 2.19% too many drugs for the same indications, 1.64% of each drug did not comply with treatment guidelines, inappropriate drugs due to contraindications, and 0.55% inappropriate duplication of active substance. There was an association between DRP and patient clinical outcomes but not significant. Recommendation, Better collaboration among doctors, pharmacists, and other health workers is needed to obtain safe and effective treatment outcomes.
Keywords: clinical outcome, drug-related problem, ischemic stroke.
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