Impact of Text Message Reminders on Drug Adherence in Post-Liver Transplant Patients
Abstract
Non-adherence among post liver transplant recipients may lead to serious consequences. Hence, there is a dire need to improve medication adherence, particularly among post-liver transplant recipients. Till date, no sufficient data has been published related to our study from Sindh province or even from Pakistan. Therefore, this study will not only help highlight the rate of Medication non-adherence but also implementation of a particular method that could be more helpful to improve the adherence among the study population. The main objective of this study was to determine medication adherence in post-liver transplant recipients before and after text message remainders. A cross sectional study was conducted on 103 post liver transplant patients at Pir Abdul Qadir Shah Institute of Medical Sciences Gambat. BAASIS Scale was used to measure medication adherence among study subjects, after that text messages reminders were given to enrolled patients and adherence was measured again using the same scale to determine the impact of text message reminders on adherence. Among enrolled patients, majority of the study subjects were male, whereas only one participant was transgender. Mostly patients belong to rural areas. Majority of the patients were of matriculation pass, while minorities of the patients were primary pass. Majority of the patients were unemployed, while few had non-government jobs, whereas government job study subjects were in minority. Majority of the patients were of age from 41 to 50, where minority of the patients were aged from 61 to 70. Majority of the patients were prescribed four drugs, whereas no any patient was prescribed only one drug. Majority of the patients were prescribed two immunosuppressant drugs while only few study subjects were prescribed only one immunosuppressant drug. Initially 86% patients were non-adherent to therapy, but after text message reminders, adherence was improved from 24% to 80%. This study concluded that the rate of adherence was improved by giving text message reminders to the patients.
Keywords: adherence, non-adherence, immunosuppressant, liver transplant.
Full Text:
PDFReferences
MARTIN P., MARTINI A., FENG S., BROWN JR. R. S., and FALLON M. Evaluation for Liver Transplantation in Adults: 2013 Practice Guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation. Hepatology, 2014, 59(3): 1144-1165. https://doi.org/10.1002/hep.26972
MENDES K. D. S., ROSSIN F. M., ZIVIANI L. C., CASTRO-E-SILVA O., and GALVÃO C. M. Necessidades de informação de candidatos ao transplante de fígado: o primeiro passo do processo ensino-aprendizagem. Revista Gaúcha de Enfermagem, 2012, 33(4): 94-102. https://doi.org/10.1590/S1983-14472012000400012
NASSETTA K., HUSSAIN T., GAMBETTA K., LE K., O’DWYER L. C., and BADAWY S. M. A Systematic Review of Adherence to Immunosuppression among Pediatric Heart Transplant Patients. Journal of Cardiovascular Development and Disease, 2022, 9(5): 165. https://doi.org/10.3390/jcdd9050165
GUNES H., BULBULOGLU S., and SARITAŞ S. Investigation of adherence to immunosuppressive therapy and spiritual well-being in liver recipients. Transplant Immunology, 2022, 72: 101585. https://doi.org/10.1016/j.trim.2022.101585
PINSKY B. W., TAKEMOTO S. K., LENTINE K. L., BURROUGHS T. E., SCHNITZLER M. A., and SALVALAGGIO P. R. Transplant Outcomes and Economic Costs Associated with Patient Noncompliance to Immunosuppression. American Journal of Transplantation, 2009, 11(9): 2597-2606. https://doi.org/10.1111/j.1600-6143.2009.02798.x
CHISHOLM M. A., MULLOY L. L., and DIPIRO J. T. Comparing renal transplant patients’ adherence to free cyclosporine and free tacrolimus immunosuppressant therapy. Clinical Transplantation, 2005, 19(1): 77-82. https://doi.org/10.1111/j.1399-0012.2004.00301.x
MORRISON A., STAUFFER M. E., and KAUFMAN A. S. Defining medication adherence in individual patients. Patient Preference and Adherence, 2015, 9: 893-897. https://doi.org/10.2147/PPA.S86249
OLIVEIRA R. A., TURRINI R. N. T., and POVEDA V. B. Adherence to immunosuppressive therapy following liver transplantation: an integrative review. Revista Latino-Americana de Enfermagem, 2016, 24: e2778. https://doi.org/10.1590/1518-8345.1072.2778
CORRER C. J., OTUKI M. F., and SOLER O. Assistência farmacêutica integrada ao processo de cuidado em saúde: gestão clínica do medicamento. Revista Pan-Amazônica de Saúde, 2011, 2(3): 41-49. http://dx.doi.org/10.5123/S2176-62232011000300006
LAMBA S., NAGURKA R., DESAI K. K., CHUN S. J., HOLLAND B., and KONERU B. Self-reported non-adherence to immune-suppressant therapy in liver transplant recipients: demographic, interpersonal, and intrapersonal factors. Clinical Transplantation, 2012, 26(2): 328-335. https://doi.org/10.1111/j.1399-0012.2011.01489.x
DEW M. A., DIMARTINI A. F., DE VITO DABBS A., MYASKOVSKY L., STEEL J., UNRUH M., SWITZER G. E., ZOMAK R., KORMOS R. L., and GREENHOUSE J. B. Rates and risk factors for nonadherence to the medical regimen after adult solid organ transplantation. Transplantation, 2007, 83(7): 858-873. https://doi.org/10.1097/01.tp.0000258599.65257.a6
DE BLESER L., DOBBELS F., BERBEN L., VANHAECKE J., VERLEDEN G., NEVENS F., and DE GEEST S. The spectrum of nonadherence with medication in heart, liver, and lung transplant patients assessed in various ways. Transplant International, 2011, 24(9): 882-891. https://doi.org/10.1111/j.1432-2277.2011.01296.x
DOBBELS F., LUT B., DE GEEST S., DRENT G., LENNERLING A., WHITTAKER C., KUGLER C.; TRANSPLANT360 TASK FORCE. The Psychometric Properties and Practicability of Self-Report Instruments to Identify Medication Nonadherence in Adult Transplant Patients: A Systematic Review. Transplantation, 2010, 90(2): 205–219. https://doi.org/10.1097/tp.0b013e3181e346cd
MARSICANO EDE O., FERNANDES NDA S., COLUGNATI F., GRINCENKOV F. R., FERNANDES N. M., DE GEEST S., and SANDERS-PINHEIRO H. Transcultural adaptation and initial validation of Brazilian-Portuguese version of the Basel assessment of adherence to immunosuppressive medications scale (BAASIS) in kidney transplants. BMC Nephrology, 2013, 14: 108. https://doi.org/10.1186/1471-2369-14-108
DE OLIVEIRA P. C., PAGLIONE H. B., SILVA E SILVA V., SCHIRMER J., and DE AGUIAR ROZA B. Measurement of non-adherence to immunosuppressive medication in liver transplantation recipients. Acta Paulista de Enfermagem, 2019, 32(3): 319-326. https://doi.org/10.1590/1982-0194201900044
WHITSETT M. and LEVITSKY J. Medication Nonadherence in Liver Transplantation. Clinical Liver Disease, 2017, 10(6): 157-160. https://doi.org/10.1002/cld.680
NGUYEN T.-M.-U., LA CAZE A., and COTTRELL N. Validated adherence scales used in a measurement guided medication management approach to target and tailora medication adherence intervention: a randomised controlled trial. BMJ Open, 2016, 6: e013375. http://dx.doi.org/10.1136/bmjopen-2016-013375
GANJALI R., GHORBAN SABBAGH M., NAZEMIYAN F., MAMDOUHI F., BADIEE AVAL S., TAHERZADEH Z., HESHMATI NABAVI F., GOLMAKANI R., TOHIDINEZHAD F., and ESLAMI S. Factors Associated with Adherence to Immunosuppressive Therapy and Barriers in Asian Kidney Transplant Recipients. ImmunoTargets and Therapy, 2019, 8: 53-62. https://doi.org/10.2147/ITT.S212760
GIRGENTI R., TROPEA A., BUTTAFARRO M. A., RAGUSA R., and AMMIRATA M. Quality of Life in Liver Transplant Recipients: A Retrospective Study. International Journal of Environmental Research and Public Health, 2020, 17(11): 3809. https://doi.org/10.3390/ijerph17113809
MOAYED M. S., KHATIBAN M., NASSIRI TOOSI M., KHODAVEISI M., SOLTANIAN A. R., and EBADI A. Barriers to Adherence to Medical Care Programs in Liver Transplant Recipients: A Qualitative Study. International Journal of Organ Transplantation Medicine, 2019, 10(3): 115-126.
JONES L. S. and SERPER M. Medication non-adherence among liver transplant recipients. Current Hepatology Reports, 2020, 19: 327–336. https://doi.org/10.1007/s11901-020-00545-7
Refbacks
- There are currently no refbacks.