Simultaneous Analysis of the Active Ingredients in Ecstasy Tablet as Hyper-Active Drug
Abstract
Ecstasy is used with various ingredients, such as methamphetamine (MET), acetaminophen (ACE), caffeine (COF), and ephedrine (EPH). These active compounds can cause problems in determining tablet levels in the laboratory. So a method is needed that is cheaper, effective, and fast to determine the tablet content. This study aims to develop a spectrophotometric subtraction of ratio spectra method for the simultaneous analysis of MET, EPH, COF, and ACE on ecstasy tablets without separation. The research was conducted using a spectrophotometric method with the subtraction of ratio spectra method using methanol and a validity test with linearity, accuracy, precision, detection limit (DL), and quantitative limit (QL) parameters. This method was applied to determine MET, EPH, COF, and ACE levels simultaneously in ecstasy tablets. The results showed that the reduction of the ratio spectra method for MET, EPH, COF, and ACE was determined simultaneously at 258 nm, 257nm, 273 nm, and 246 nm. The percentage level is 38.83% for MET, 32.13% for EPH, 19.05% for COF, and 10.39% for ACE. The subtraction of ratio spectra method met the validation parameters, including linearity, accuracy, precision, DL, and QL. It can be concluded that the can subtraction of ratio spectra method is used for simultaneous determination of levels for ecstasy tablets containing MET, EPH, COF, and ACE using methanol as a solvent and meets the validation parameter requirements.
Keywords: methamphetamine, ephedrine, caffeine, acetaminophen, the subtraction of ratio spectra method.
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