Histological and Biochemical Evaluation of the Effect of Desloratadine Drug in Hepatic Tissues
The main active element of loratadine (Claritin) is desloratadine (Clarinex), a non-sedating antihistamine used to treat pollen allergies and hives. The liver is responsible for drug metabolism, bioregulation, and immunomodulation. As a result, the impact of different desloratadine doses on hepatic tissues, histological characteristics, and serum liver enzymes is explored in this research. Materials and methods: In this work, thirty rats were utilized. Three organizations were made (each containing ten rats). Controls rat (Group A)./Desloratadine was given to groups B and C for 3 weeks at doses of 0.142 mg per kilogram of body weight and 0.245 mg per kilogram, respectively. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in the blood were measured three weeks later; three groups had their alkaline phosphatase (ALP) levels measured. Animals were then sacrificed, and five µm formalin-fixed paraffin-embedded tissue blocks from the liver were consistently produced for histological assessment under a light microscope. The histological evaluation of hepatic tissues in both treated-groups was revealed a great dilatation, congestion, edema, and necrosis, degeneration, infiltration, and atrophy of liver tissue. The treated groups had significantly increased AST, ALT, and ALP serum levels regarding the biochemical analysis. Desloratadine administration produces noticeable histological changes in a dose-dependent manner associated with increased liver enzymes AST, /ALT, and ALP.
Keywords: desloratadine, histamine, CYP3A4, liver, histology, hepatotoxicity
KAZMI F., YERINO P., BARBARA J. E., and PARKINSON A. Further characterization of the metabolism of desloratadine and its cytochrome P450 and UDP-glucuronosyltransferase (UGT) inhibition potential: Identification of desloratadine as a relatively selective UGT2B10 inhibitor. Drug Metabolism and Disposition, 2015, 43(9): 1294-1302. https://doi.org/10.1124/dmd.115.065011
DUDOK O., & LUTSYK A. Structural and lectin-detectable changes of liver induced by a long-term administration of antihistamine agent Loratadine. Journal of Medical Science, 2016, 85(2): 114-120. https://doi.org/10.20883/jms.2016.113
TANG H., XU M., LUO J., ZHAO L., YE G., SHI F., LV C., CHEN H., WANG Y., and LI Y. Liver toxicity assessments in rats following sub-chronic oral exposure to copper nanoparticles. Environmental Sciences Europe, 2019, 31: 30. https://doi.org/10.1186/s12302-019-0214-0
SAEED M. G., NOOMI B. S., and SARHAT E. R. Relation between Level of Some Immunological Markers and Liver Functions with Respiratory Bacterial Infection in Sheep. Indian Journal of Forensic Medicine & Toxicology, 2021, 15(4), 1924-1929. https://doi.org/10.37506/ijfmt.v15i4.16985
HASSAN N. F., SOLIMAN G. M., OKASHA E. F., and SHALABY A. M. Histological, immunohistochemical, and biochemical study of experimentally induced fatty liver in adult male albino rat and the possible protective role of pomegranate. Journal of Microscopy and Ultrastructure, 2018, 6(1): 44-55. https://doi.org/10.4103/jmau.jmau_5_18
AL-MADANY N. A., & SARHAT E. R. Determination of Some Biochemical Parameters of Patients with Hepatitis B in Kirkuk City. Kirkuk University Journal Scientific Studies, 2018, 13(2): 139-148. http://dx.doi.org/10.32894/kujss.2018.145724
ZHU Y., LIU C., CHEN X., LU S., and CHEN J. Hepatoprotective effects and mechanisms of Ixeris denticulate water extract on liver cirrhosis in the experimental rat. BioMedCentral Complement Medic Therapies, 2020, 20: 175. https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-020-02957-w
KAID F., ALABSI A. M., ALAFIFI N., ALI-SAEED R., AL-KOSHAB M. A., RAMANATHAN A., and ALI A. M. Histological, Biochemical, and Hematological Effects of Goniothalamin on Selective Internal Organs of Male Sprague-Dawley Rats. Journal of Toxicology, 2019: 6493286. https://doi.org/10.1155/2019/6493286
SARHAT E. R., WADI S. A., and ABDULHAMEED B. Effect of phenolic compounds Extraction of Green tea (Camellia Sinensis L.) On the Glutathione of Alloxan Experimental Induced Diabetic Rabbit. Tikrit Journal of Pharmaceutical Sciences, 2008, 4(2): 117-125. https://www.researchgate.net/publication/320087152_effect_of_phenolic_compounds_Extraction_of_green_tea_Camellia_sinnesis_Lon_the_Glutathion_of_Alloxan_Eperimental_Induced_-Diabetic_rabbit
ABDULLAH B. A., WADI S. A., and SARHAT E. R. Histological Study Effects of Paracetamol on Livers and Kidneys of Adult Mice. Journal of Tikrit University for Agricultural Sciences, 17: 97-103. https://www.researchgate.net/publication/321485834_Histological_study_effects_of_paracetamol_on_livers_and_kidneys_of_adult_mice
SEDEEQ B. I., SARHAT E. R., WADEE S. A., and SARHAT T. R. Effects of indomethacin Administration on Some Biochemical and brain histological Changes in Male Rats. Indian Journal of Forensic Medicine & Toxicology, 2021, 15(3): 2127-2135. https://doi.org/10.37506/ijfmt.v15i3.15630
MOHAMMED I. J., SARHAT E. R., WADEE S. A., and AL-SHIAKHANI S. M. Histological and Biochemical Evaluation of the Effect of Desloratadine Drug in Parotid Gland Tissues. Al-Anbar Medical Journal: 1-6. https://www.academia.edu/45603143/Histological_and_Biochemical_Evaluation_of_the_Effect_of_Desloratadine_Drug_in_Parotid_Gland_Tissues
SARHAT E. R., WADEE S. A., SEDEEQ B. I., and SARHAT T. R. Biochemical and Histological Evaluation of Indomethacin-induced Hepatotoxicity in Rats. Indian Journal of Forensic Medicine & Toxicology, 2018, 10(4): 733-735. https://www.jpsr.pharmainfo.in/Documents/Volumes/vol10Issue04/jpsr10041808.pdf
PANIAGUA A. C., & AMARILES P. Pharmacokinetics and Adverse Effects of Drugs - Mechanisms and Risks Factors. IntechOpen, London, 2018: 77- 92. https://www.intechopen.com/books/6192
SALEH S. S., & SARHAT E. R. Ethanolic Moringa Oleifera Extract Effects on Melatonin, Liver, and Kidney Function Tests in Alloxan-Induced Diabetic Rats. Indian Journal of Forensic Medicine & Toxicology, 2019, 13(4): 1015-1019. http://dx.doi.org/10.5958/0973-9130.2019.00431.6
SARHAT E. R., WADI S. A., and IBRAHIM S. K. The Influence of Lycopene on Interleukin-6, Tumor Necrosis Factor -α, Alanine Aminotransferase, Aspartate Aminotransferase Levels in Streptozotocin-Induced Diabetic Rabbits. In 3rd Scientific Conferenc of College of Veterinary. Medicine University of Tikrit, Tikrit, 2016: 1-5.
SARHAT E. R., WADI S. A., SEDEEQ B., SARHAT T. R., and JASIM N. A. Study of the histopathological and biochemical effect of Punica granatum L. extract on Streptozotocin-induced diabetes in rabbits. Iraqi Journal of Veterinary Sciences, 2019, 33(1): 189-194. https://doi.org/10.33899/IJVS.2019.125523.1045
- There are currently no refbacks.