Effect of Treatment with Cleome Scaposa DC and Cleome Viscose L on Plasma Cholesterol and Atherogenic Index

Muslim Abbas, Shahid Ali, Yasir Murtaza, Shabnam Khan, Sadaf Fatima, Santosh Kumar Sidhwani


This study aims to evaluate the effect of Cleome scaposa DC and Cleome viscose L on the lipid profile in Albino rabbits. The goal of the study was to discover newer ways to treat hyperlipidemia. Thirty albino rabbits were randomly divided into three groups (n = 10, per group). The daily oral dosing of ethanol extract of Cleome scaposa DC and ethanol extract of Cleome viscose L was administered respectively to groups1 and 2, while group 3 was considered the control group. Blood samples were taken at the end of the first, second, and fourth weeks. There was significant reduction in total cholesterol (F2, 4 = 10.85, P < 0.05), triglyceride levels (F2, 4 = 1.686, P < 0.05) and low-density lipoprotein (LDL) levels (F2, 4 = 1.97, P < 0.045) in the treated groups of albino rabbits. A significant increase was seen in high-density lipoprotein (HDL) levels (F2, 4 = 29.095, P < 0.05) in both groups treated. Cleome scaposa and Cleome viscose decreased total cholesterol. Both the herbs possess various constituents, which would be beneficial for treating different diseases. Studies regarding the phytochemistry of these herbs will be required before knowing the mechanism of action.


Keywords: Cleome scaposa, Cleome viscose, albino rabbits.




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