Role of Presepsin and Comparison with Conventional Markers for Early Diagnosis and Differentiation of Sepsis
Abstract
Sepsis is a fatal condition that contributes to most deaths in health care setups worldwide. Early diagnosis of sepsis could alleviate this growing mortality rate. However, it remained a challenging task due to the lack of specific biomarkers. This study aimed to analyze the utility of novel Presepsin to indicate the early onset of sepsis and distinguish it from systemic inflammatory response syndrome compared to conventional markers. We have conducted a cross-sectional study on 38 patients who recently developed septicemia and 90 systemic inflammatory syndrome cases. Demographic data and results of initial laboratory workup for sepsis, blood culture, procalcitonin, and C-reactive protein were obtained for comparison. The plasma levels of Presepsin were significantly higher in the sepsis patients (p<0.001) with the highest sensitivity (81.6%), specificity (70%), and area under the curve (0.87). Strong statistical association of C-reactive protein and sepsis was determined despite lower validity and area under the curve. Relatively lower validity indices and receiver operating curve were found for procalcitonin, while culture appeared to be the least effective marker for early diagnosis of sepsis. Conclusively, the study showed that Presepsin could serve as a new biomarker for sepsis. Hence, we recommend revision in current management guidelines of sepsis for inclusion of Presepsin to already existing biomarkers for accurate early diagnosis and differentiation of sepsis.
Keywords: sepsis, systemic inflammatory response syndrome, soluble CD14-subtype, presepsin.
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