Glycemic Control and Hepatoprotective Effects of Curcuma Longa Supplementation in Patients with Type 2 Diabetes

Waseem Abbas, Rafeeq Alam Khan, Mirza Tasawar Baig, Safder Ali Shaikh, Andeep Kumar


This study aimed to determine the effect of Cucurma longa L supplementation on blood glucose and albumin levels and the hepatoprotective action 3 g C. longa divided in three doses during a 60-day treatment. The goal of this investigation, which is a prospective cohort study conducted in a tertiary care hospital, was to evaluate the effect and safety of C. longa, a natural supplement for the management of diabetes. Ninety subjects were divided into a treatment group and a control group, each consisting of 45 individuals. The control group was given an antidiabetic agent without C. longa supplementation, whereas the treatment group was given C. longa supplementation, along with a prescribed antidiabetic medication. Blood samples were collected by venous puncture to measure the random blood sugar, albumin, ALT, and AST levels before and 60 days after C. longa supplementation. The results were analyzed using SPSS version 20, and values were expressed as mean ± standard error. After the 60-day treatment, the random blood sugar level significantly decreased in the treatment group, which received glimepiride, metformin, and C. longa capsule, relative to that in the control group, which received glimepiride and metformin only (195.73 ± 16.34 mg/dl vs. 264.53 ± 19.69 mg/dl). No significant change in the albumin, ALT, and AST levels were observed between the groups, indicating that C. longa exerts no hepatotoxicity. It could be concluded that C. longa supplementation is safe and that it significantly reduces blood glucose levels in diabetic patients. This is the only study that evaluates the effect of C. longa supplementation on glycemic control in diabetic patients in Pakistan.

Keywords: type 2 diabetes, Curcuma longa, random blood sugar, albumin, aspartate aminotransferase, alanine transaminase.

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