The Effect of Variant Concentration of Kesambi (Scheleichera Oleosa) on Diabetic Animal Models
Abstract
Diabetes mellitus (DM) is a disease with high prevalence which continues to increase. Existing treatments, either orally or through insulin injection, has varied effectiveness for diabetics. Therefore, an alternative treatment of DM is needed. Kesambi leaves have antioxidant properties, which are thought to have potential as an antidiabetic. Antioxidants are compounds that can reduce the negative impact of free radicals and other oxidants, to inhibit oxidative damage that could worsen the severity of DM. This study aims to determine the antioxidant compound content of kesambi extract and its effects on glucose, insulin, and regeneration of pancreatic beta cells in Wistar rats induced by streptozotocin. Methods: Experimental research with modified pretest and posttest randomized controlled group design, using 60 male Wistar rats divided into 6 thin-layer chromatography (TLC) groups: healthy, sick (streptozocin (STZ) induction), galvus (synthetic drug), and kesambi extract at levels of 100, 200, and 300 mg/Kg BB male Wistar rats. The study showed that kesambi (Schleichera oleosa) extract had antioxidant activity of inhibitory concentration (IC) 50 of 20.29 ppm (very strong), effected the regeneration of pancreatic β cells, improved insulin levels, and decreased blood glucose levels of Wistar rats induced by STZ, dosed optimally at a concentration of 200 mg to improve regeneration of pancreatic β cells, insulin levels and decreased blood glucose levels.
Keywords: diabetes mellitus, insulin, glucose, kesambi (Schleichera oleosa), β-pancreas.
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