Insecticides Exposure during Early Life Alters Prostate Cells Differentiation in Adulthood Spraque Dawley Rat

Tri Indah Winarni, Indra Wijaya, Henna Rya Sunoko, Susilo Wibowo


 Exposure of endocrine disruptor chemicals during early life may alter prostate morphogenesis and cellular differentiation, associated with an increased risk of prostatic intraepithelial neoplasia (PIN). This study was designed to elucidate the effect of early insecticide exposure in the prostate gland. Newborn male Spraque Dawley rats were allocated into untreated (control) and treated groups, including estrogen potent (25 mg b estradiol 3-benzoate), mosquito coil repellent, and liquid mosquito repellent. Prostate luminal epithelial and periductal stromal cells were significantly altered among mosquito insecticide groups [mosquito coil repellent (p < 0.001), 3-ml (p < 0.002), and 4-ml liquid mosquito repellent (p < 0.009)] and [mosquito coil repellent (p < 0.001), 3-ml (p < 0.05) and 4-ml liquid mosquito repellent (p = 0.05)] compared to those of control group, respectively. Mosquito insecticide exposure during early life leads to an alteration of prostate cellular differentiation in adulthood that may predispose to prostate cancer.



Keywords: early life exposure, endocrine disruptor chemicals, insecticides exposure, mosquito repellent, prostate cancer.





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