Advancements in Mucoadhesive Delivery Systems for Gastroenterology
Abstract
This review aimed to provide a comprehensive overview of recent advancements and applications of mucoadhesive delivery systems specifically designed for the treatment and diagnosis of gastrointestinal (GI) tract diseases. This review focuses on the potential of these systems to address the challenges associated with conventional dosage forms, offering insights for researchers, clinicians, and pharmaceutical professionals involved in the development of innovative GI therapies. The review examines various mucoadhesive delivery systems, including tablets, pellets, gels, and micro/nanoparticles, and details their formulations and mechanisms of action. Special attention is paid to the interaction between these delivery systems and the complex GI environment. The analysis included a comparative evaluation of different systems to highlight their respective benefits and limitations in enhancing drug residence time and achieving targeted, sustained drug release. Our findings suggest that mucoadhesive properties significantly improve the performance of drug delivery systems in the GI tract by increasing residence time and ensuring more controlled, localized drug release. Each system presents unique attributes that make it a promising candidate for improving therapeutic outcomes in gastroenterology. This review highlights the enhanced efficacy of mucoadhesive systems compared with traditional methods. The review highlights the innovative potential of mucoadhesive delivery systems in overcoming the limitations of conventional dosage forms, particularly in the context of GI diseases. By improving drug delivery precision and retention in the GI tract, these systems represent significant advancements in pharmaceutical technology, offering new avenues for both diagnosis and treatment.
Keywords: gastrointestinal tract; gastroenterology; mucoadhesive delivery system; gastric mucosa
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