Physical Stability Profiling and Toxicity Index of Novel Integrated Organollopathic Dental Rinse Solution
Abstract
Oral washes for mouth and teeth are a sterile preparation process with anti-inflammatory properties against periodontal diseases. This research was planned to design mouthwash with an herbal-allopathic integrated formulation. Keeping one's teeth and mouth clean has been a common practice since ancient times and throughout all of human history. Mouthwash is a type of fluid that is considered a powerful and safe device that is used to flush the mouth to prevent dental caries, eliminate oral microorganisms, and act as an astringent. This also reduces the risk of life-threatening strains that arise from sewer water or food. The aim was to evaluate the novelty safety, efficacy, quality, toxicity, and side effects through pre-clinical trials on mice before commercialization. The toxicity indexes applied were physical behavior, hematology, and histopathology tests, performed against NMRI mice. No animals were found dead or in any serious abnormal condition, and normal development was observed, according to our interpretations. When compared to the control groups, it was discovered that body weight remained within normal ranges. The physical stability included monitoring of PH and density at room and accelerated temperatures for two years. The results showed that new developed oral solution met the standard criteria without causing any harmful side effects on weight, major organs, and blood patterns in mice. Acute toxicity revealed no mortality. Organollopathic (biosol) mouthwash formulations are one of the exceptionally compelling constituents for controlling the development of microorganisms and prevention of damaging health problems such as gingivitis, plaque and biofilm infections without causing any toxicity and maintaining the density and PH level.
Keywords: histology, periodontitis, stability, oral hygiene, hematology.
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