Association between Polymorphism Locus rs7041 and rs4588 in VDBP Gene and Vitamin D Status with Mortality in Sepsis Patient

Liliriawati Ananta Kahar, Yusrawati Yusrawati, Jamsari Jamsari, Tinni Maskoen, Kornelis Aribowo, Wiwi Monika Sari


Vitamin D deficiency was associated with an increased mortality risk in patients with sepsis. Loci rs7041 and rs4588 polymorphisms of the Vitamin D Binding Protein (VDBP) gene receptor caused a significantly increased risk of vitamin D deficiency in subtropical countries (Yordania). Simultaneously, similar studies for the tropics (Indonesia) have not been found yet. This study aims to analyze the association between polymorphism locus rs7041 and rs4588 in the vitamin D binding receptor gene and vitamin D status with the mortality of sepsis patients. This study was an analytical observation type with a cohort design. The relationship between the two groups was analyzed using the chi-square test/fisher test. Mutant’s polymorphism locus rs7041 in not survived patients is more than survived (65.0% vs. 35.0%) with a p-value of 0,025. The mortality risk was 1.625 times (RR 1.625 95% CI 1.044 – 2.529). The mutant’s polymorphism locus rs4588 locus in not survived patients is more than survived (70.3% vs. 29.7%) with a p-value of 0,022. The mortality risk was 1.622 times (RR 1.622 95% CI 1.095 – 2.402). Polymorphism loci rs7041 and rs4588 in not survived sepsis patients were higher mutants than the wild type. The highest vitamin D deficiency occurred in the mutant locus rs4588 (55.5%), but it was not statistically significant p > 0.05. There was an association between Loci rs7041 and rs4588 polymorphisms and mortality of sepsis patients. No association was between Loci rs7041 and rs4588 polymorphisms with vitamin D status and between vitamin D status and mortality of patients with sepsis.


Keywords: polymorphism, rs7041, rs4588, vitamin D, vitamin D binding protein, mortality, sepsis.

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