A Prospective Study on Cephalosporin Consumption Pattern at Trust-Based Tertiary Care Hospital

Awais Ahmed Juno, Mirza Tasawer Baig, Amber Noorani, Rabeeya Qutubuddin Siddiqui, Sajjad Ahmed Abbasi, Bilal Mustafa, Kirshan, Altaf Ali Mangi

Abstract

This study aimed to evaluate the Drug usage of 3rd generation cephalosporins and its effectiveness against particular diagnosis. A Prospective cross-sectional study was conducted at 40 Bedded Pediatric wards of Sukkur Blood Bank, Donating Society and Hospital, Sukkur to evaluate the antibiotic usage pattern among all admitted in-patients. Patients’ demographic details were recorded from the Patient Bedside File (PBF). Data were analyzed using an excel sheet and Microsoft SPSS 20. Among all admitted patients, 1710 patients met the inclusion criteria and their PBF were evaluated for antibiotics. A total of 2155 cephalosporins were prescribed. The most commonly prescribed cephalosporins among the study population were Ceftriaxone 51.55% followed by Cefotaxime Sodium (26.50%). Among all, 74.34% pediatric patients were prescribed antibiotics through the parenteral route and 25.66% through the oral route. Antibiotics were being used without having any official national antibiotic policy or institutional protocols, which are currently lacking in the country. The study findings shall assist the health department and hospital management to devise the official guidelines to ensure rational usage of antibiotics. It is therefore recommended that the government should immediately address the irrational and overuse of antibiotics by implementing, national antibiotics policy, antibiotic stewardship programs, and training of healthcare staff. Novelty of this paper consists of collection of large-scale data, also data from diversified population was collected, as this study was conducted in public, private, and also charity-based hospitals.

 

Keywords: pediatrics, antibiotics, cephalosporins, consumption pattern, culture sensitivity test.

 

https://doi.org/10.55463/issn.1674-2974.50.1.29


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References


AMERICAN ACADEMY OF PEDIATRICS COMMITTEE ON PEDIATRIC WORKFORCE. Pediatrician workforce statement. Pediatrics, 2005, 116(1), 263–269. https://doi.org/10.1542/peds.2005-0873

MISHRA H, MISHRA R, and MONDAL A. Prescription pattern of antimicrobial drugs in pediatrics outpatient department of a tertiary care teaching hospital of North India. International Journal of Basic & Clinical Pharmacology, 2014, 3(2): 385-388

FELEKE M, YENET W, and LENJISA JL. Prescribing pattern of antibiotics in pediatric wards of Bishoftu Hospital, East Ethiopia. International Journal of Basic & Clinical Pharmacology, 2013, 2(6):718-22

SHEA K, FLORINI K, and BARLAM T. When Wonder Drugs Don’t Work: How Antibiotic Resistance Threatens Children, Seniors, and The Medically Vulnerable. Washington: Environmental Defense, 2002. Available at: https://www.edf.org/sites/default/files/162_abrreport.pdf

AHMADI F, & ZAREI E. Prescribing patterns of rural family physicians: a study in Kermanshah Province, Iran. BMC Public Health, 2017, 17(1): 908

CIMINO MA, KIRSCHBAUM MS, BRODSKY L, & SHAHA SH. Child Health Accountability Initiative: Assessing medication prescribing errors in pediatric intensive care units. Pediatric Critical Care Medicine, 2004, 5(2): 124-132.

FINKELSTEIN JA, STILLE C, NORDIN J, et al. Reduction in antibiotic use among US children, 1996–2000. Pediatrics, 2003, 112(3): 620-627

ATIF M, AZEEM M, SAQIB A, & SCAHILL S. Investigation of antimicrobial use at a tertiary care hospital in Southern Punjab, Pakistan using WHO methodology. Antimicrobial Resistance and Infection Control, 2017, 6, 41. https://doi.org/10.1186/s13756-017-0199-7

ALAKHALI KM, and MOHAMMAD AA. Prescribing pattern of antibiotics in pediatric patients in the Jazan region, Kingdom of Saudi Arabia. RGUHS Journal of Pharmaceutical Sciences, 2014, 4(3): 120-124.

BYTYQI HQ, HOXHA R, BAHTIRI E, et al. Antibiotic utilization in pediatric hospitalized patients- A single center study. Open Access Macedonian Journal of Medical Sciences, 2017, 5(2): 256-280.

MURNI IK, DUKE T, KINNEY S, et al. Reducing hospital-acquired infections and improving the rational use of antibiotics in a developing country: An effectiveness study. Archives of Disease in Childhood, 2015, 100(5): 454-459

FATIMA R, BAIG MT, ARSALAN A, et al. Irrational Use of Quinolones in Tertiary Care Hospital Karachi, Pakistan. International Journal of Medical Research & Health Sciences, 2020, 9(8): 9-12

WHO Collaborating Center for Drug Statistics Methodology. ATC/DDD Index 2013. Oslo, Norway2013 [cited 2013 March]; Available from: http://www.whocc.no/atc_ddd_index/

RISK R, NAISMITH H, BURNETT A, et al. Rational prescribing in pediatrics in a resource-limited setting. Archives of Disease in Childhood, 2013, 98(7): 503-509.

OKOMO UA, DIBBASEY T, KASSAMA K, et al. Neonatal admissions, quality of care and outcome: 4 years of inpatient audit data from the Gambia’s teaching hospital. Paediatrics and International Child Health, 2015, 35(3): 252-264.

GIRMA S, SISAY M, MENGISTU G, et al. Antimicrobial Utilization Pattern in Pediatric Patients in Tertiary Care Hospital, Eastern Ethiopia: The Need for Antimicrobial Stewardship. Hospital Pharmacy Journal, 2017, 53(1): 44-54

SHAMSHY K, BEGUM IM, & PERUMAL P. Drug utilization of antimicrobial drugs in pediatrics population in a tertiary care hospital in Erode. Tamil Nadu, India International Journal of PharmTech Research, 2011, 3: 1530-1536.

WOLDU MA, SULEMAN S, WORKNEH N, & BERHANE H. Retrospective study of pattern of antibiotic use in Hawassa University Referral Hospital, Pediatric ward, Southern Ethiopia. Journal of Applied Pharmaceutical Science, 2013, 3: 93-98.

SAWALHA A, AL-BISHTAWI G, & AL-KHAYYAT L. Pattern of parenteral antimicrobial prescription among pediatric patients in Al-Watani Governmental Hospital Palestine. An-Najah University Journal for Research (Science), 2006, 20: 198-208

ANYANWU N, & ARIGBE-OSULA M. Pattern of antibiotic use in a tertiary hospital in Nigeria. European Journal of Hospital Pharmacy: Science and Practice, 2012, 19: 195-195

ACHALU TS, YIMAM B, & KEBEDE KM. Antibiotic utilization pattern in pediatric ward: the case from Tertiary Teaching Hospital. South West Ethiopia International Journal of Advanced Multidisciplinary Research, 2015, 2: 54-61.

MESTAWOT F, WUBANTE Y, & JIMMA LL. Prescribing pattern of antibiotics in pediatric wards of Bishoftu Hospital. East Ethiopia International Journal of Basic Clinical Pharmacology, 2013, 2(6): 718-722.

ATIF M, AZEEM M, SARWAR MR, et al. WHO/INRUD prescribing indicators and prescribing trends of antibiotics in the Accident and Emergency Department of Bahawal Victoria Hospital, Pakistan Springer Plus, 2016, 5, 1928. https://doi.org/10.1186/s40064-016-3615-1

JARUSEVICIENE L, RADZEVICIENE-JURGUTE R, LAZARUS J V, et al. A study of antibiotic prescribing: the experience of Lithuanian and Russian GPs. Central European Journal of Medicine, 2012, 7: 790-799.

SVIESTINA I, ASTON J, & MOZGIS D. Comparison of antimicrobial prescribing between two specialist paediatric centres in the UK and Latvia. European Journal of Hospital Pharmacy: Science and Practice, 2013, 20: 180-184.

MEZGEBE HB, TADESSE B, & LEGESSE B. Antibiotic prescribing pattern in pediatric unit of Ayder Referral Hospital, Tigray region, Northern Ethiopia. Journal of Scientific and Innovative Research, 2015, 4: 57–60.

PRABAHAR K, DINESH S, BARIA S, & PADMASANI LN. Antibiotic utilization pattern in Pediatrics in a Tertiary Care Teaching Hospital. Asian Journal of Pharmaceutics, 2017, 1191, 230-230.

CASEY JR, & PICHICHERO ME. Meta-analysis of Cephalosporin versus penicillin treatment of group A Streptococcal tonsillopharyngitis in children. Clinical Infectious Disease, 2004, 3(11): 1526-1534.

SHIVALEELA D, JAGADEESH DK, VEDAVATHI D, & CHIDANAND D. A study of prescription pattern of antibiotics in pediatric in-patients of Mcgann teaching hospital Shivamogga institute of medical sciences (SIMS), Shivamogga, Karnataka. IOSR – Journal of Dental and Medical Sciences, 2014, 13(12): 67-71

CHOUDHURY CK, & BEZBARUAH BK. Antibiotic Prescription pattern in pediatric inpatient department, Guwahati medical college and hospital. Journal of Applied Pharmaceutical Science, 2013, 3: 144-148.


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