Effects of Humactents and Oleogeneous Base in the Photostabilization of Secnidazole Emulgels

Sidrah Hassan, Hina Abrar, Mirza Tasawer Baig, Hina Yasin, Kaneez Fatima, Hira Naeem, Affan Ali, Kiran Qadeer, Kishan Das, Ayaz Ali Khan, Adeel Arsalan

Abstract

This investigation aims to study the formulation of emulgel preparations of secnidazole (SZ, The variables in the composition of the oleaginous phase (liquid paraffin and castor oil) and humectants (propylene glycol and glycerol) and the physical and rheological properties like homogeneity, spreadability, and extrudability were studied. Variations in the viscosity of SZ emulgels were observed due to changes in formulations. The viscosity was central to the stability of the SZ emulgel preparations. SZ is a photosensitive drug, and irradiation formed its primary photodegraded product 2,4-(N-2-hydroxypropyl) diaza-3-methyl-1-nitro-1,5-dione. SZ has been subjected to photolysis by irradiation, and the clear first-order rate constant, kobs, for the degradation of SZ has been determined. The values of kobs (2.79-5.12 × 10-2 min-1) have decreased with the increase in viscosity (20085-29985 cP) of emulgel preparations. The ratio of stabilization is in the range of 2.31-4.22. It is concluded that increasing the viscosity of pharmaceutical preparations may enhance the photostability of light-sensitive drugs.

 

Keywords: secnidazole, emulgel, viscosity, kinetics, photostabilization.

 

https://doi.org/10.55463/issn.1674-2974.49.12.11


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