Comparative Quantitative Evaluation of Marketed Available Dexibuprofen Product: Assessment of Quality, Effectiveness and Interchangeability

Amber Nawab, Safila Naveed, Huma Ali, Javeria Rafique, Subia Jamil, Shaheen Parveen


NSAIDs are the most consumable class of drugs used in daily life for a number of ailments like analgesia, anti-inflammatory, antipyretic effect. One of the racemic NSAIDs of the parent drug ibuprofen is Dexibuprofen. As reported in numerous studies, Dexibuprofen is more potent in effect. Dexibuprofen can be interchanged in the clinical practice. This research focuses on the comparative analysis of different commercial brands of Dexibuprofen from different perspectives, including physicochemical properties, pharmacokinetic properties, and pharmacopeial properties. A comparison of Dexibuprofen will provide significant aspects of this product and show its cost effectiveness and interchangeability. Different tests were performed on six marketed common brands of Dexibuprofen. The results were compared and analyzed using different statistical tools and presented in tables are graphs. All the brands followed USP/BP guidelines and their properties lie within acceptable ranges, it has been observed in research through statistical tools that all these six brands in terms of hardness, thickness, weight variation, and dissolution profile (at different pH media) showed significance, which indicates that all the brands have similarities in their properties and significant variations in drug performance of all marketed brands in different pH as dissolution medium at different time intervals. Although in certain points of percentages the results indicate the superiority of brands 01 (DS) in many properties but due to the high price of this brand it might not be preferred in common population, while study concludes that all brands are similar in comparative analysis in different properties and followed by guidelines, they exhibit acceptable properties and are safe to use.


Keywords: Dexibuprofen, non-steroidal anti-inflammatory drugs, marketed brands, comparative analysis.

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